In a world with skyrocketing inflation and unemployment, blood has become the new commodity, and the rarer your blood type, the more it's worth. After losing her job and watching her savings dwindle, Liri is persuaded by a resourceful friend to sell her blood to ABO Blood Group, where she learns she is O Negative, the most valuable and sought after blood. Unable to afford living in New York City, Liri reluctantly decides to move back home and live with her parents, but her plan is interrupted when a virus is maliciously unleashed onto the island of Manhattan, resulting in a citywide quarantine. Before being able to devise an alternative plan, she is secretly informed of a covert mission by ABO to evacuate Negatives out of NYC. Although reluctant to trust them, it's her only viable choice to stay alive, but unbeknown to Liri, she and the Negatives are vital to activating opposing agendas on Earth and beyond.