One - Methodology.- I. Left ventricular and Coronary Cineangiography; Overview of Techniques, Applications and Limitations.- Left ventricular cineangiography.- Cardiac volume.- Regional wall motion.- Wall motion models.- Left ventricular reference systems.- Left ventricular coordinate systems.- Validation studies various left ventricular wall motion models.- Coronary cineangiography.- Inter- and intraobserver variations in visual interpretation.- Number of projections.- Further limitations assessment lesion severity.- Physiological significance coronary obstruction.- Haemodynamics coronary obstruction.- ''Critical lesion''.- Discrepancy relative obstruction measures and its functional significance.- Indirect approaches towards the assessment of the functional significance of obstructions.- Videodensitometry.- Pulsed Doppler coronary catheter.- Thallium-201 mycocardial imaging.- Positron-emission tomography.- Radionuclide washout techniques.- Digital radiography.- References.- II Cineangiocardiography.- Contrast agents.- The radiologic image.- The X-ray generator and tube.- X-ray absorption.- Image intensifier.- Optics and cinecamera.- Cinefilm exposure.- Cinefilm processing.- Film processing unit.- Video system.- Quality control.- Clinical factors in cineangiocardiography.- References.- III. Cardiovascular Angiography Analysis System (CAAS) 62.- Architecture Thoraxcenter CAAS.- Cine-video converter.- Calibration procedure.- Pincushion correction.- Contour detection of arterial segment.- Contour analysis.- Assessment severity of coronary obstruction.- Mean diameter arterial segment.- Hemodynamic parameters coronary obstruction.- Analysis time coronary cineangiogram.- Pie Data CAAS.- Cinefilm digitizer.- Data acquisition procedure.- References.- IV. Contouromat - A hard-wired left ventricular angio processing system.- General description.- Basic techniques.- Left ventricular data acquisition procedure (MAXI-cine).- Left ventricular data acquisition procedure (MINI-cine).- Automatically detected ED- and ES- contours.- Manual tracking ED- and ES- contours.- Left ventricular data analysis procedure (MAXI-cine).- Left ventricular data analysis procedure (MINI-cine).- Concluding remarks.- References.- V. Validation quantitation techniques of coronary and left ventricular cineangiograms.- A. Accuracy and precision contour detection technique.- B. Variability data analysis procedure.- C. Overall variabilities of repeated coronary cineangiography and computer analysis.- Statistical analysis.- Short-term (5 min.) variability.- Medium-term (1 hour) variability.- Long-term (90 days) variability.- D. Discussion evaluation data CAAS.- Technical characteristics.- Sources of error in angiographic and analysis procedures.- Variabilities of acquisition and analysis procedures.- E. Performance evaluation Contouromat.- Average processing time per cineframe.- Percentage of cineframes requiring one or more manual corrections.- Average number of corrections per corrected cineframe and volume effects of corrections.- F. Discussion evaluation data Contouromat.- References.- VI. Assessment of dimensions and image quality of coronary contrast catheters from cineangiograms.- Summary.- Methods.- Materials.- Results.- Discussion.- References.- VII. Densitometric analysis coronary cineangiograms.- The X-ray-Cine-Video imaging system.- Transfer functions of the different system components.- X-ray beam attenuation.- Image intensifier.- Cinefilm exposure.- Film digitizer.- Analog-to-digital conversion.- Relationship between measured brightness level and object attenuation factor.- Practical applications.- Densitometry from contrast image.- Gated subtraction method.- Evaluation study.- Concluding remarks.- References.- VIII. 3-D reconstruction of coronary arterial segments from two projections.- Problem analysis and overview of pertinent literature.- Basic principles.- Cost coefficient matrix.- Noise considerations.- Registration of the two orthogonal projections.- Clinical example.- Preliminary evaluation 3-D reconstruction algorithms.- References.- IX. Structural analysis of the coronary and retinal arterial trees 185.- Overview of other approaches.- Methodology.- Preprocessing.- Segmentation in first frame.- Frame-to-frame segmentation.- Model/data synchronization.- Three-dimensional epicardial motion.- Applications.- Analysis of retinal fluorescein angiograms.- The RFT cinerecording of retinal flow.- Detection of the retinal arterial vessel patterns.- Measurement flow velocities in retinal vessels.- Concluding remarks analysis retinal images.- References.- X. A methodological review of quantification systems for coronary and left ventricular cineangiograms.- Quantitative coronary cineangiography.- Cinefilm conversion.- Contour detection coronary arterial segment.- Definition global centerline.- Edge enhancement.- Contour definition.- Pincushion correction.- Calibration.- Contour analysis.- Densitometry.- Three-dimensional reconstruction.- Concluding remarks.- Quantitative left ventricular cineangiography.- Light-pen computer processing.- Off-line processing of left ventricular cineangiograms.- On-line processing of left ventricular angiograms.- Analog video processing.- Digital image processing.- Concluding remarks.- References.- XI Quantitative assessment of regional left ventricular function: Endocardial landmark motion.- Summary.- Materials and methods.- Results.- Endocardial wall motion in pigs.- Endocardial wall motion in humans.- Discussion.- References.- XII. The cardiovascular database and the coronary reporting system.- CAAS database.- Coronary reporting system.- Summary.- References.- Two - Clinical Applications.- XIII. Influence of intracoronary nifedipine on left ventricular function, coronary vasomotility, and myocardial oxygen consumption 275.- Summary.- Patients and methods.- Patients and design of the study.- Analysis of isovolumic indices during ventriculography.- Analysis of global and regional left ventricular function during systole and diastole.- Coronary sinus blood flow measurement and myocardial oxygen consumption.- Quantitative coronary angiography.- Results.- Global systolic and diastolic left ventricular function.- Regional left ventricular function.- Coronary sinus blood flow and myocardial oxygen consumption.- Quantitative coronary cineangiography.- Discussion.- Global and regional left ventricular function.- Coronary blood flow and myocardial oxygen consumption.- Quantitative coronary angiography.- Conclusion.- References.- XIV. Effect of intracoronary thrombolytic therapy on global and regional left ventricular function. A three years experience with randomization.- Summary.- Patient selection and methods.- Patient selection.- Study protocol.- Analysis of global and regional LV function.- Statistical analysis.- Results.- Discussion.- References.- XV. Effect of coronary occlusion during percutaneous transluminal angioplasty in man on left ventricular chamber stiffness and regional diastolic pressure-radius relations.- Summary.- Patients and methods.- Patients.- Study protocol.- Data analysis.- Calculations.- Statistical analysis.- Results.- Discussion.- References.- XVI. Is transluminal coronary angioplasty mandatory after successful thrombolysis? A quantitative coronary angiographic study 326.- Summary.- Patients and methods.- Technique of intracoronary streptolysis.- Technique of percutaneous transluminal coronary angioplasty.- Quantitative angiographic analysis.- Results.- Patency of the infarct related vessel, acute and chronic stage.- Quantitative angiographic analysis.- Discussion.- References.- XVII. Assessment of percutaneous transluminal coronary angioplasty by quantitative coronary angiography: diameter versus densitometric area measurements.- Summary.- Methods.- Quantitative analysis of coronary obstructions.- Study population.- Results.- Discussion.- References.- XVIII. Left ventricular performance, regional blood flow, wall motion and lactate metabolism during transluminal angioplasty.- Summary.- Materials and methods.- Study population and protocol.- Analysis of pressure-derived indices during systole and diastole.- Determination of relaxation parameters.- Semilogarithmic model.- Exponential model.- Derivative model.- Analysis of global and regional left ventricular function during systole and diastole.- Results.- Analysis of pressure-derived indices during systole and diastole.- Global left ventricular function during systole and diastole.- Regional left ventricular function.- Coronary blood flow and lactate metabolism.- Discussion.- Global and regional left ventricular performance.- Coronary hemodynamics.- Metabolic disturbances.- Clinical implications.- References.- XIX. The role of vascular wall thickening during changes in coronary artery tone.- Summary.- Methods.- Patients selection and test procedure.- Quantitative angiographic analysis.- Geometric considerations: dynamic vascular wall thickening.- Results.- Discussion.- References.- XX. Responses of normal and obstructed coronary arterial segments to cold stimulation; a quantitative angiographic study.- Summary.- Methods.- Study population.- Coronary angiography and cold stimulation.- Quantitative angiographic analysis.- Statistical analysis.- Results.- Changes in arterial dimensions in non-obstructed segments induced by CPT.- Diameter changes by CPT in different non-obstructed segments.- Responses of stenotic segments and lesions to CPT.- Discussion.- References.- XXI Quantitative angiography of the left anterior descending coronary artery: correlations with pressure gradient and exercise thallium scintigraphy.- Summary.- Methods.- Patients selection.- Quantitative coronary angiography.- Noninvasive testing.- Statistical analysis.- Results.- Discussion.- References.- XXII. Quantitative coronary angiography in a lipid intervention study (The Leiden Diet Intervention Trial).- Summary.- Methods.- Patients.- Diet.- Biochemical measurements.-