A road trip is all that's on Lydia Proctor's mind, especially after working two difficult genealogy projects that both turned into to solving a murder from the past. This time out Lydia and her friends, Muriel, Faye and Julia are attending a genealogy conference in Virginia. This may sound boring to the average person but for the girls it's a way to learn new techniques, make new friends and bond with each other. It isn't until they attend a case study lecture that their idyllic trip turns in a totally different direction. A well known African-American genealogist needs help. It's his brick wall and he feels as if he can't see the answer anymore. It's not just a random case study, it's personal to him, his ancestor was accused of murder. Reluctantly Lydia volunteers herself and the group to try and help solve this cold case. But as always it isn't what it seems and Lydia must come out of her comfort zone to help someone she admires come to terms with his family, and help him close the door on A Case Study in Murder.