The harsh, unforgiving frontier is no place for innocents. And when an old friend of the Preacher's asks him to guide a gaggle of wide-eyed easterners throught the Rockies, Preacher responds with a polite, "Hell no". But the pilgrims are pursued by a gang of outlaws and then ambushed by angry Indians. With his friend caught up in the melee, Preacher has no choice but to try to rescue him and anyone else who happens to be within reach.