Entheogenesis means the growing realization that we human beings and the world around us are much more than simply material organisms living and evolving on a material planetary body. We are multi-dimensional spiritual, cosmic, noetic, psychic and physical beings. The central insight that emerges from entheogenic states and is confirmed by the perennial spiritual traditions of East and West, is that at every level, from macro-cosmic to micro-cosmic, from atoms and animals, to trees and planets and stars, Spirit dwells within created forms and expresses through them. This monograph is based on 50 years of experience as a participant-observer in the international underground sub-culture involved with entheogenic, consciousness-expanding substances. The author discusses the uses and values of such substances when the explicit intention or purpose is for spiritual awakening, psychotherapy, healing, increased understanding and the enhancement of creativity. The intent of this documentation is not to prove or promote any particular method or treatment of any condition. The evaluation of entheogens needs to be in terms of how productive these experiences are of healthier approaches to the issues of of living in these times, in this world.