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Unwieldy Creatures, a biracial, queer, nonbinary retelling of Mary Shelley's classic novel Frankenstein, follows the story of three beings who all navigate life from the margins: Plum, a queer biracial Chinese intern at one of the world's top embryology labs, who runs away from home to openly be with her girlfriend only to be left on her own; Dr. Frank, a queer biracial Indonesian scientist, who compromises everything she claims to love in the name of science and ambition when she sets out to procreate without sperm or egg; and Dr. Frank's nonbinary creation who, painstakingly brought into the world, is abandoned due to complications at birth that result from a cruel twist of revenge. Plum struggles to determine the limits of her own ambition when Dr. Frank offers her a chance to assist with her next project. How far will Plum go in the name of scientific advancement and what is she willing to risk?