London: November 1905. England and the world are changing. Into the rooms of Sherlock Holmes come Nikola Tesla and Thomas Edison-with new inventions that will alter the course of human history-only both inventions have gone missing. Can Holmes, Watson, and Irene Adler somehow unravel the latest diabolical scheme of Marie Chartier-evil daughter of the late Professor Moriarty? Can world peace be achieved by the most powerful weapon ever created? Can death itself be overcome by a scientific genius? And can Sherlock Holmes survive the greatest personal loss of his career?